Publications

@article{Wu2024,

title = {Mesoscopic calcium imaging in a head-unrestrained male non-human primate using a lensless microscope},

author = {Jimin Wu and Yuzhi Chen and Ashok Veeraraghavan and Eyal Seidemann and Jacob T. Robinson},

doi = {10.1038/s41467-024-45417-6},

issn = {2041-1723},

year  = {2024},

date = {2024-12-00},

journal = {Nat Commun},

volume = {15},

number = {1},

publisher = {Springer Science and Business Media LLC},

abstract = {AbstractMesoscopic calcium imaging enables studies of cell-type specific neural activity over large areas. A growing body of literature suggests that neural activity can be different when animals are free to move compared to when they are restrained. Unfortunately, existing systems for imaging calcium dynamics over large areas in non-human primates (NHPs) are table-top devices that require restraint of the animal’s head. Here, we demonstrate an imaging device capable of imaging mesoscale calcium activity in a head-unrestrained male non-human primate. We successfully miniaturize our system by replacing lenses with an optical mask and computational algorithms. The resulting lensless microscope can fit comfortably on an NHP, allowing its head to move freely while imaging. We are able to measure orientation columns maps over a 20 mm2 field-of-view in a head-unrestrained macaque. Our work establishes mesoscopic imaging using a lensless microscope as a powerful approach for studying neural activity under more naturalistic conditions.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Zhou2024,

title = {Disparate nonlinear neural dynamics measured with different techniques in macaque and human V1},

author = {Jingyang Zhou and Matt Whitmire and Yuzhi Chen and Eyal Seidemann},

doi = {10.1038/s41598-024-63685-6},

issn = {2045-2322},

year  = {2024},

date = {2024-12-00},

journal = {Sci Rep},

volume = {14},

number = {1},

publisher = {Springer Science and Business Media LLC},

abstract = {AbstractDiverse neuro-imaging techniques measure different aspects of neural responses with distinct spatial and temporal resolutions. Relating measured neural responses across different methods has been challenging. Here, we take a step towards overcoming this challenge, by comparing the nonlinearity of neural dynamics measured across methods. We used widefield voltage-sensitive dye imaging (VSDI) to measure neural population responses in macaque V1 to visual stimuli with a wide range of temporal waveforms. We found that stimulus-evoked VSDI responses are surprisingly near-additive in time. These results are qualitatively different from the strong sub-additive dynamics previously measured using fMRI and electrocorticography (ECoG) in human visual cortex with a similar set of stimuli. To test whether this discrepancy is specific to VSDI\textemdasha signal dominated by subthreshold neural activity, we repeated our measurements using widefield imaging of a genetically encoded calcium indicator (GcaMP6f)\textemdasha signal dominated by spiking activity, and found that GCaMP signals in macaque V1 are also near-additive. Therefore, the discrepancies in the extent of sub-additivity between the macaque and the human measurements are unlikely due to differences between sub- and supra-threshold neural responses. Finally, we use a simple yet flexible delayed normalization model to capture these different dynamics across measurements (with different model parameters). The model can potentially generalize to a broader set of stimuli, which aligns with previous suggestion that dynamic gain-control is a canonical computation contributing to neural processing in the brain.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Chen2024,

title = {Neural correlates of perceptual similarity masking in primate V1},

author = {Spencer Chin-Yu Chen and Yuzhi Chen and Wilson S Geisler and Eyal Seidemann},

doi = {10.7554/elife.89570},

issn = {2050-084X},

year  = {2024},

date = {2024-04-09},

volume = {12},

publisher = {eLife Sciences Publications, Ltd},

abstract = {Visual detection is a fundamental natural task. Detection becomes more challenging as the similarity between the target and the background in which it is embedded increases, a phenomenon termed ‘similarity masking’. To test the hypothesis that V1 contributes to similarity masking, we used voltage sensitive dye imaging (VSDI) to measure V1 population responses while macaque monkeys performed a detection task under varying levels of target-background similarity. Paradoxically, we find that during an initial transient phase, V1 responses to the target are enhanced, rather than suppressed, by target-background similarity. This effect reverses in the second phase of the response, so that in this phase V1 signals are positively correlated with the behavioral effect of similarity. Finally, we show that a simple model with delayed divisive normalization can qualitatively account for our findings. Overall, our results support the hypothesis that a nonlinear gain control mechanism in V1 contributes to perceptual similarity masking.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Becker2024,

title = {Exact Analysis of the Subthreshold Variability for Conductance-Based Neuronal Models with Synchronous Synaptic Inputs},

author = {Logan A. Becker and Baowang Li and Nicholas J. Priebe and Eyal Seidemann and Thibaud Taillefumier},

doi = {10.1103/physrevx.14.011021},

issn = {2160-3308},

year  = {2024},

date = {2024-02-00},

journal = {Phys. Rev. X},

volume = {14},

number = {1},

publisher = {American Physical Society (APS)},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{zhou2023delayed,

title = {Delayed normalization model captures disparate nonlinear neural dynamics measured with different techniques in macaque and human V1},

author = {Jingyang Zhou and Matt Whitmire and Yuzhi Chen and Eyal Seidemann},

doi = {https://doi.org/10.1101/2023.01.30.525700},

year  = {2023},

date = {2023-01-01},

urldate = {2023-01-01},

journal = {bioRxiv},

pages = {2023\textendash01},

publisher = {Cold Spring Harbor Laboratory},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{chen2022similar,

title = {Similar neural and perceptual masking effects of low-power optogenetic stimulation in primate V1},

author = {Spencer Chin-Yu Chen and Giacomo Benvenuti and Yuzhi Chen and Satwant Kumar and Charu Ramakrishnan and Karl Deisseroth and Wilson S Geisler and Eyal Seidemann},

doi = {DOI: 10.7554/eLife.68393},

year  = {2022},

date = {2022-01-01},

urldate = {2022-01-01},

journal = {Elife},

volume = {11},

pages = {e68393},

publisher = {eLife Sciences Publications Limited},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{Bai2021,

title = {Similar masking effects of natural backgrounds on detection performances in humans, macaques, and macaque-V1 population responses},

author = {Yoon Bai and Spencer Chen and Yuzhi Chen and Wilson S. Geisler and Eyal Seidemann},

doi = {10.1152/jn.00275.2020},

issn = {1522-1598},

year  = {2021},

date = {2021-06-01},

urldate = {2021-06-01},

journal = {Journal of Neurophysiology},

volume = {125},

number = {6},

pages = {2125--2134},

publisher = {American Physiological Society},

abstract = {\<jats:p\> We measured macaque detection performance in natural images and compared their performance to the detection sensitivity of neurophysiological responses recorded in the primary visual cortex (V1), and to the performance of human subjects. We found that 1) human and macaque behavioral performances are in quantitative agreement and 2) are consistent with near‐optimal decoding of V1 population responses. \</jats:p\>},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{trautmann2021dendritic,

title = {Dendritic calcium signals in rhesus macaque motor cortex drive an optical brain-computer interface},

author = {Eric M Trautmann and Daniel J O’Shea and Xulu Sun and James H Marshel and Ailey Crow and Brian Hsueh and Sam Vesuna and Lucas Cofer and Gerg\H{o} Bohner and Will Allen and ... and Eyal Seidemann and ... and Karl Deisseroth and Krishna Shenoy},

url = {https://www.nature.com/articles/s41467-021-23884-5},

year  = {2021},

date = {2021-01-01},

urldate = {2021-01-01},

journal = {Nature Communications},

volume = {12},

number = {1},

pages = {1--20},

publisher = {Nature Publishing Group},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{li2020voltage,

title = {Voltage-gated intrinsic conductances shape the input-output relationship of cortical neurons in behaving primate V1},

author = {Baowang Li and Brandy N Routh and Daniel Johnston and Eyal Seidemann* and Nicholas J Priebe*},

url = {https://doi.org/10.1016/j.neuron.2020.04.001},

doi = {https://doi.org/10.1016/j.neuron.2020.04.001},

year  = {2020},

date = {2020-01-01},

urldate = {2020-01-01},

journal = {Neuron},

volume = {107},

number = {1},

pages = {185--196},

publisher = {Cell Press},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{tremblay2020open,

title = {An open resource for non-human primate optogenetics},

author = {S\'{e}bastien Tremblay and Leah Acker and Arash Afraz and Daniel L Albaugh and Hidetoshi Amita and Ariana R Andrei and Alessandra Angelucci and Amir Aschner and Puiu F Balan and Michele A Basso and ... and Eyal Seidemann and ... and Michael L. Platt},

url = {https://doi.org/10.1016/j.neuron.2020.09.027},

doi = {https://doi.org/10.1016/j.neuron.2020.09.027},

year  = {2020},

date = {2020-01-01},

urldate = {2020-01-01},

journal = {Neuron},

volume = {108},

number = {6},

pages = {1075--1090},

publisher = {Cell Press},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{chen2020uniform,

title = {Uniform spatial pooling explains topographic organization and deviation from receptive-field scale invariance in primate V1},

author = {Y Chen and H Ko and BV Zemelman and E Seidemann and I Nauhaus},

url = {https://doi.org/10.1038/s41467-020-19954-9},

doi = {https://doi.org/10.1038/s41467-020-19954-9},

year  = {2020},

date = {2020-01-01},

urldate = {2020-01-01},

journal = {Nature communications},

volume = {11},

number = {1},

pages = {1--14},

publisher = {Nature Publishing Group},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{mehta2019functional,

title = {Functional access to neuron subclasses in rodent and primate forebrain},

author = {Preeti Mehta and Lauren Kreeger and Dennis C Wylie and Jagruti J Pattadkal and Tara Lusignan and Matthew J Davis and Gergely F Turi and Wen-Ke Li and Matthew P Whitmire and Yuzhi Chen and others},

url = {https://doi.org/10.1016/j.celrep.2019.02.011},

doi = {https://doi.org/10.1016/j.celrep.2019.02.011},

year  = {2019},

date = {2019-01-01},

urldate = {2019-01-01},

journal = {Cell reports},

volume = {26},

number = {10},

pages = {2818--2832},

publisher = {Cell Press},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{seidemann2018linking,

title = {Linking V1 activity to behavior},

author = {Eyal Seidemann and Wilson S Geisler},

url = {https://doi.org/10.1146/annurev-vision-102016-061324},

doi = {https://doi.org/10.1146/annurev-vision-102016-061324},

year  = {2018},

date = {2018-01-01},

urldate = {2018-01-01},

journal = {Annual review of vision science},

volume = {4},

pages = {287--310},

publisher = {Annual Reviews},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{michel2018nonlinear,

title = {Nonlinear Lateral Interactions in V1 Population Responses Explained by a Contrast Gain Control Model},

author = {Melchi M Michel and Yuzhi Chen and Eyal Seidemann and Wilson S Geisler},

url = {https://doi.org/10.1523/jneurosci.0246-18.2018},

doi = {https://doi.org/10.1523/jneurosci.0246-18.2018},

year  = {2018},

date = {2018-01-01},

urldate = {2018-01-01},

journal = {Journal of Neuroscience},

volume = {38},

number = {47},

pages = {10069--10079},

publisher = {Society for Neuroscience},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{benvenuti2018scale,

title = {Scale-invariant visual capabilities explained by topographic representations of luminance and texture in primate V1},

author = {Giacomo Benvenuti and Yuzhi Chen and Charu Ramakrishnan and Karl Deisseroth and Wilson S Geisler and Eyal Seidemann},

url = {https://doi.org/10.1016/j.neuron.2018.10.020},

doi = {https://doi.org/10.1016/j.neuron.2018.10.020},

year  = {2018},

date = {2018-01-01},

urldate = {2018-01-01},

journal = {Neuron},

volume = {100},

number = {6},

pages = {1504--1512},

publisher = {Cell Press},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{morais2017majority,

title = {Majority of choice-related variability in perceptual decisions is present in early sensory cortex},

author = {Michael J Morais and Charles D Michelson and Yuzhi Chen and Jonathan W Pillow and Eyal Seidemann},

doi = {https://doi.org/10.1101/207357},

year  = {2017},

date = {2017-01-01},

urldate = {2017-01-01},

journal = {bioRxiv},

pages = {207357},

publisher = {Cold Spring Harbor Laboratory},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{seidemann2016calcium,

title = {Calcium imaging with genetically encoded indicators in behaving primates},

author = {Eyal Seidemann and Yuzhi Chen and Yoon Bai and Spencer C Chen and Preeti Mehta and Bridget L Kajs and Wilson S Geisler and Boris V Zemelman},

url = {https://doi.org/10.7554/elife.16178},

doi = {https://doi.org/10.7554/elife.16178},

year  = {2016},

date = {2016-01-01},

urldate = {2016-01-01},

journal = {Elife},

volume = {5},

pages = {e16178},

publisher = {eLife Sciences Publications Limited},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{yang2015long,

title = {Long-range traveling waves of activity triggered by local dichoptic stimulation in V1 of behaving monkeys},

author = {Zhiyong Yang and David J Heeger and Randolph Blake and Eyal Seidemann},

url = {https://doi.org/10.1152/jn.00610.2013},

doi = {https://doi.org/10.1152/jn.00610.2013},

year  = {2015},

date = {2015-01-01},

urldate = {2015-01-01},

journal = {Journal of neurophysiology},

volume = {113},

number = {1},

pages = {277--294},

publisher = {American Physiological Society Bethesda, MD},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{tan2014sensory,

title = {Sensory stimulation shifts visual cortex from synchronous to asynchronous states},

author = {Andrew YY Tan and Yuzhi Chen and Benjamin Scholl and Eyal Seidemann* and Nicholas J Priebe*},

url = {https://doi.org/10.1038/nature13159},

doi = {https://doi.org/10.1038/nature13159},

year  = {2014},

date = {2014-01-01},

urldate = {2014-01-01},

journal = {Nature},

volume = {509},

number = {7499},

pages = {226--229},

publisher = {Nature Publishing Group},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{michel2013illusion,

title = {An illusion predicted by V1 population activity implicates cortical topography in shape perception},

author = {Melchi M Michel and Yuzhi Chen and Wilson S Geisler and Eyal Seidemann},

url = {https://doi.org/10.1038/nn.3517},

doi = {https://doi.org/10.1038/nn.3517},

year  = {2013},

date = {2013-01-01},

urldate = {2013-01-01},

journal = {Nature neuroscience},

volume = {16},

number = {10},

pages = {1477--1483},

publisher = {Nature Publishing Group},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{chen2012relationship,

title = {The relationship between voltage-sensitive dye imaging signals and spiking activity of neural populations in primate V1},

author = {Yuzhi Chen and Chris R Palmer and Eyal Seidemann},

url = {https://doi.org/10.1152/jn.00977.2011},

doi = {https://doi.org/10.1152/jn.00977.2011},

year  = {2012},

date = {2012-01-01},

urldate = {2012-01-01},

journal = {Journal of neurophysiology},

volume = {107},

number = {12},

pages = {3281--3295},

publisher = {American Physiological Society Bethesda, MD},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{palmer2012uniform,

title = {Uniform spatial spread of population activity in primate parafoveal V1},

author = {Chris R Palmer and Yuzhi Chen and Eyal Seidemann},

url = {https://doi.org/10.1152/jn.00117.2011},

doi = {https://doi.org/10.1152/jn.00117.2011},

year  = {2012},

date = {2012-01-01},

urldate = {2012-01-01},

journal = {Journal of neurophysiology},

volume = {107},

number = {7},

pages = {1857--1867},

publisher = {American Physiological Society Bethesda, MD},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{chen2012attentional,

title = {Attentional modulations related to spatial gating but not to allocation of limited resources in primate V1},

author = {Yuzhi Chen and Eyal Seidemann},

url = {https://doi.org/10.1016/j.neuron.2012.03.033},

doi = {https://doi.org/10.1016/j.neuron.2012.03.033},

year  = {2012},

date = {2012-01-01},

urldate = {2012-01-01},

journal = {Neuron},

volume = {74},

number = {3},

pages = {557--566},

publisher = {Elsevier},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{sit2009complex,

title = {Complex dynamics of V1 population responses explained by a simple gain-control model},

author = {Yiu Fai Sit and Yuzhi Chen and Wilson S Geisler and Risto Miikkulainen and Eyal Seidemann},

url = {https://doi.org/10.1016/j.neuron.2009.08.041},

doi = {https://doi.org/10.1016/j.neuron.2009.08.041},

year  = {2009},

date = {2009-01-01},

urldate = {2009-01-01},

journal = {Neuron},

volume = {64},

number = {6},

pages = {943--956},

publisher = {Elsevier},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{chen2008optimal,

title = {Optimal temporal decoding of neural population responses in a reaction-time visual detection task},

author = {Yuzhi Chen and Wilson S Geisler and Eyal Seidemann},

url = {https://doi.org/10.1152/jn.00698.2007},

doi = {https://doi.org/10.1152/jn.00698.2007},

year  = {2008},

date = {2008-01-01},

urldate = {2008-01-01},

journal = {Journal of neurophysiology},

volume = {99},

number = {3},

pages = {1366--1379},

publisher = {American Physiological Society},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{palmer2007linking,

title = {Linking neuronal and behavioral performance in a reaction-time visual detection task},

author = {Chris Palmer and Shao-Ying Cheng and Eyal Seidemann},

url = {https://doi.org/10.1523/JNEUROSCI.1940-07.2007},

doi = {https://doi.org/10.1523/JNEUROSCI.1940-07.2007},

year  = {2007},

date = {2007-01-01},

urldate = {2007-01-01},

journal = {Journal of Neuroscience},

volume = {27},

number = {30},

pages = {8122--8137},

publisher = {Society for Neuroscience},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{yang2007rapid,

title = {Rapid and precise retinotopic mapping of the visual cortex obtained by voltage-sensitive dye imaging in the behaving monkey},

author = {Zhiyong Yang and David J Heeger and Eyal Seidemann},

url = {https://doi.org/10.1152/jn.00417.2007},

doi = {https://doi.org/10.1152/jn.00417.2007},

year  = {2007},

date = {2007-01-01},

urldate = {2007-01-01},

journal = {Journal of neurophysiology},

volume = {98},

number = {2},

pages = {1002--1014},

publisher = {American Physiological Society},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{chen2006optimal,

title = {Optimal decoding of correlated neural population responses in the primate visual cortex},

author = {Yuzhi Chen and Wilson S Geisler and Eyal Seidemann},

url = {https://doi.org/10.1038/nn1792},

doi = {https://doi.org/10.1038/nn1792},

year  = {2006},

date = {2006-01-01},

urldate = {2006-01-01},

journal = {Nature neuroscience},

volume = {9},

number = {11},

pages = {1412--1420},

publisher = {Nature Publishing Group},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{pmid11823644,

title = {Dynamics of depolarization and hyperpolarization in the frontal cortex and saccade goal},

author = {Eyal Seidemann and Amos Arieli and Amiram Grinvald and Hamutal Slovin},

doi = {10.1126/science.1066641},

issn = {1095-9203},

year  = {2002},

date = {2002-02-01},

journal = {Science},

volume = {295},

number = {5556},

pages = {862--865},

abstract = {The frontal eye field and neighboring area 8Ar of the primate cortex are involved in programming and execution of saccades. Electrical microstimulation in these regions elicits short-latency contralateral saccades. To determine how spatiotemporal dynamics of microstimulation-evoked activity are converted into saccade plans, we used a combination of real-time optical imaging and microstimulation in behaving monkeys. Short stimulation trains evoked a rapid and widespread wave of depolarization followed by unexpected large and prolonged hyperpolarization. During this hyperpolarization saccades are almost exclusively ipsilateral, suggesting an important role for hyperpolarization in determining saccade goal.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{seidemann1998temporal,

title = {Temporal gating of neural signals during performance of a visual discrimination task},

author = {Eyal Seidemann and Ehud Zohary and William T Newsome},

doi = {https://doi.org/10.1038/27906},

year  = {1998},

date = {1998-01-01},

urldate = {1998-01-01},

journal = {Nature},

volume = {394},

number = {6688},

pages = {72\textendash75},

publisher = {Nature Publishing Group UK London},

keywords = {},

pubstate = {published},

tppubtype = {article}

}