- We develop and use a wide range of optical, genetic and electrophysiological tools for measuring (“reading”) and manipulating (“writing”) neuronal responses while animals perform demanding perceptual tasks.
- We open an maintain a large cranial window that provides direct optical access (for imaging and optogenetic stimulation) and physical access (for electrophysiology, whole-cell intracellular recording and viral injections) to the brain.
- We use methods for widefield (one-photon) imaging of genetically-encoded calcium and voltage indicators and synthetic voltage sensitive dyes.
- We use multi-photon imaging to measure dense cellular and sub-cellular resolution cell-type specific neural responses.
- We develop single-photon and multi-photon optogenetic techniques for manipulating neural responses while simultaneously imaging neural responses to visual stimuli and/or to optogenetic stimulation.
- We closely collaborate with bioengineers to test new cutting-edge technologies that could be used for future brain-computer interface devices and at the same time could advance our basic understanding of neural circuits and the neural code.